Probing the Complexities of Myelodysplastic Syndromes
نویسندگان
چکیده
منابع مشابه
Myelodysplastic Syndromes Myelodysplastic syndromes: recent advances
Etiology of myelodysplastic syndromes The models for the development of sporadic MDS suggest the role of cumulative environmental exposures in genetically predisposed individuals. There is increasing evidence for a complex genetic predisposition to MDS involving naturally occurring DNA polymorphisms in genes that mediate DNA repair and metabolize environmental carcinogens.3 Large epidemiologic ...
متن کاملUnderstanding the Myelodysplastic Syndromes.
The myelodysplastic syndrome (MDS) remains challenging to the clinician in terms of diagnosis and management. The diagnosis is essentially one of exclusion in first ruling out other disorders that can also cause peripheral blood/bone marrow cell dysplasia and cytopenias. The distinguishing biological characteristic of MDS is that it is a clonal disorder of the marrow with impaired differentiati...
متن کاملThe Myelodysplastic Syndromes.
The myelodysplastic syndromes (MDS) are a heterogeneous group of disorders characterized by peripheral blood cytopenias with a hypercellular bone marrow exhibiting dyspoiesis. The MDS range from those with a relatively indolent course (e.g., refractory anemia with or without ringed sideroblasts) to more aggressive disorders (e.g., refractory anemia with excess blasts [RAEB], and RAEB in transfo...
متن کاملThe myelodysplastic syndromes.
The concept of preleukaemia originated early in this century with the recognition of prodromal haematological abnormalities in acute myeloid leukaemia.' Since then similar preleukaemic disorders have 'been described, including primary acquired sideroblastic anaemia and smouldering or oligoblastic leukaemia. Confusion created by differing connotations placed on the term preleukaemia was resolved...
متن کاملMyelodysplastic syndromes.
The myelodysplastic syndromes are a heterogeneous group of hematopoietic stem cell disorders characterized by dysplastic and ineffective hematopoiesis and a varying risk of transformation to acute leukemia. Although the natural history of these syndromes is variable, several factors appear to be of prognostic importance, including the French-American-British classification, the karyotype, in vi...
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ژورنال
عنوان ژورنال: Critical Values
سال: 2016
ISSN: 2378-8321,2378-8372
DOI: 10.1093/crival/vaw002